NMN Side Effects
Feb 04, 2021

NMN supplement side effects

Side Effects & Safety

When taken by mouth: Nicotinamide riboside is POSSIBLY SAFE when used short-term. Side effects of nicotinamide riboside are usually mild. Side effects may include stomach problems such as nausea and bloating or skin problems such as itching and sweating too much.

Currently, no side effects of nicotinamide mononucleotide have been documented in humans. Researchers have conducted the majority of studies on NMN in rodents, which revealed positive effects on metabolism, brain function, liver, skin, muscle, bone structure, heart health, reproduction, immunity, and lifespan. Long-term mice study also showed no toxicity, serious side effects, or increased mortality rate throughout the 12 month intervention period.

A single study of NMN in humans reveals no safety concerns following single oral doses of 100, 250, and 500 mg of NMN. Five hours following the single oral administration of NMN, scientists found no changes in heart rate, blood pressure, blood oxygen levels, or body temperature. Laboratory analyses of blood did not show significant changes, except with levels of four molecules in the blood, which fell within normal ranges. This study also measured sleep quality, and found no differences before and after the NMN consumption.

Scientists need to conduct further studies of NMN administration in humans to determine whether side effects come from consuming it. Scientists could look at doses higher than 500 mg to find whether they induce side effects. Research could also look at whether long-term consumption of NMN causes side effects.

nmn bulk powder

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if nicotinamide riboside is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Table 2

Positive and negative effects of NAM shown in human studies 1.

Affected Organs and Conditions 2Observed EffectsDose and DurationReferences
Beneficial effects

JointsReduced itching in uremic patients550 mg twice a day
(4 weeks)
pancreatic β-cellβ-cell function preserved and improved25 mg/kg daily intake
(4 weeks)
Reduced the rate of diabetes incidence500 mg twice per day
(2.5 years)
No effect on the incidence of being diabetes-free1200 mg daily intake
(5 years)
Ineffective in prevention or delaying clinical onset of diabetes1.2 g daily intake
(3 years)
SkinReduced acne lesions and severity4% gel
applied twice daily
(8 weeks)
Attenuated immunosuppression with alterations in metabolism and apoptosis5% lotion applied before UV exposure[40]
PsychologyImprovements against depression0.5–1.5 g daily intake
(3 weeks)
Relief from anxietyA dose of 2 ug
3 h prior to test
KidneyLowered serum concentrations of phosphorus, parathyroid hormone, and LDL, and increased serum HDL500 mg/day (with and increment every 2 weeks)
(12 weeks)
Skin cancers non-melanomaReduced incidence of various types of skin cancers and actinic keratoses500 mg twice daily
(4 months)
Adverse Effects

Minor effectsFrontal dull headaches, nausea, headache, dizziness1–18 g
Pancreatic β-cell/plasmaDecreased insulin sensitivity, increased oxidative stress (H2O2)2 g daily
(2 weeks)
LiverParenchymal-cell injury, portal fibrosis and cholestasis, liver injury3, 9 g daily
(10 days)
Lymphocytes, plateletsUremic toxicity-related cancer and thrombocytopenia1300, 1500 mg daily
(24 weeks)
Kidney/plateletsDecreased serum phosphorus and thrombocytopenia0.52–2 g daily
(3–6 months)
For bulk nmn powder, please contact us at email:


Previous: Chicoric Acid

Next: NMN Foods

  • QR Code