What is Chicoric Acid?
Chicoric acid is a hydroxycinnamic acid that occurs in a variety of plants such as Cichorium intybus and Echinacea purpurea. It has been used as an anti-viral, anti-inflammatory, antioxidant and an insulin enhancer.
Chicoric acid has specifically been used as an inhibitor of integrase enzymes in human immunodeficiency virus type one (HIV1). Inhibition of this enzyme prevents viral genetic material from being incorporated into host DNA. It specifically shows activity towards HIV1 and not HIV2.
Chicoric acid presence for in vivo and in vitro studies have shown a stimulation in AMP-activated protein kinase (AMPK) expression. The upregulation in AMPK expression results in the observed antioxidant, anti-inflammatory and insulin enhancing effects. Anti-oxidizing protein synthesis has been increased through AMPK stimulation. AMPK has also been shown to diminish inflammatory responses by increasing interleukin 10 synthesis (IL10), an anti-inflammatory cytokine. Chicoric acid stimulation of AMPK inhibits glucose-6-phosphate formation, promoting glucose utilization. The release of insulin by pancreatic β-islet cells has been correlated with direct stimulation by chicoric acid.
MW: 474.37 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 5281764
Chicoric acid (also known as cichoric acid) is a hydroxycinnamic acid, an organic compound of the phenylpropanoid class and occurs in a variety of plant species. It is a derivative of both caffeic acid and tartaric acid.
As a suitable marker for the distinction of Echinacea species, it is often assayed using RP-HPLC and Thin layer chromatography (TLC) methods.
Chicoric acid has first been isolated from Cichorium intybus (chicory) but also occurs in significant amounts in Echinacea, in particular E. purpurea, dandelion leaves, basil, lemon balm, and aquatic plants, including algae and seagrasses.
Chicoric acid has been shown to stimulate phagocytosis in both in vitro and in vivo studies, to inhibit the function of hyaluronidase (an enzyme that breaks down hyaluronic acid in the human body), to protect collagen from damage due to free radicals, and to inhibit the function of HIV-1 integrase.
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