What is Tetrahydrocurcumin?
Tetrahydrocurcumin oids (THC) is the main product of curcumin metabolism in the human body and is obtained by hydrogenation of curcumin. THC is an odorless white powder which is more hydrophilic than curcumin. It has been used as a raw material for various skin care products in the research and development of cosmetics and has broad development prospects.
Tetrahydrocurcumin is a beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds. It has a role as a metabolite. It is a beta-diketone, a polyphenol and a diarylheptanoid. It derives from a curcumin.
Tetrahydrocurcumin, a curcumin metabolite, exhibited anticancer activities against human breast cancer MCF-7 cells by the induction of mitochondrial apoptosis and cell cycle arrest in G2/M phase through the activation of p38 MAPK.
Curcumin exhibits maximum inhibition of CYP2C9 and CYP3A4 at 50 to 100 μM. It does not show a consistent dose-response inhibition of CYP1A2 or CYP2D6 over the range of concentrations tested. In some cases, the percent inhibition exceeds 100%. The effect of Tetrahydrocurcumin on cancer cell viability is measured. Sup-T1 cells, T-cell lymphoblastic lymphoma cells, are treated with it to determine its ability to induce growth inhibition using an MTS assay, and the corresponding IC50 values are in the mid-to-high micromolar range.
1.The superior antioxidant property of THC, combined with the lack of yellow color, render this product useful in achromatic food and cosmetic applications that currently employ conventional synthetic antioxidants, anti-inflammatory and antioxidant properties, as well as providing UVB protection. It scavenges and prevents the formation of free radicals. It also inhibits tyrosinase, which inhibits the skin from producing melanin. This product is color-free, unlike the brilliant yellow color of other turmeric extracts and can be used in anti-aging, skin lightening, and sun care and after sun care formulations.
2.Tetrahydrocurcuminoids (THC), a colorless hydrogenated product derived from the yellow curcuminoids, (the biologically active principles from the rhizomes of Curcuma longa), function as efficient antioxidant compounds used for skin whitening. The superior antioxidant property of Tetrahydrocurcumin, combined with the lack of yellow color, render this product useful in achromatic food and cosmetic applications that currently employ conventional synthetic antioxidants, anti-inflammatory and antioxidant properties, as well as providing UVB protection. It scavenges and prevents the formation of free radicals.
3. It also inhibits tyrosinase, which inhibits the skin from producing melanin. This product is color-free, unlike the brilliant yellow color of other turmeric extracts and can be used in anti-aging, skin lightening, and sun care and after sun care formulations. THC offer protection to the skin and should be considered for inclusion as functional antioxidants in topical preparations. Tetrahydrocurcuminoids scavenges free radicals that are generated through exposure to ultraviolet radiation, chemicals or other environmental stress factors which age the skin. The efficacy of Curcuminoids and THC is also concentration dependent, with THC being even more effective at lower concentrations.
4.Tetrahydrocurcumin also helps to improve the shelf life of topical formulations by inhibiting the autoxidation of fats by offering protection against rancidity of the fat components used in the formulation of cosmetics. The antiinflammatory effects of THC combined with their efficient antioxidant action render them useful as ingredients in anti-aging formulations, skin lightening and brightening products and topical formulations designed to maintain general skin health and integrity.
Production process flow chart:
Packing & Storage :
Packing: 25Kg/Fiber Drum, double plastic bag inside.
1Kg/Bag, aluminum foil bag vacuum packing
Storage: Kept away from strong light and heat.
Shelf Life: 24 months for powder
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