What is coenzyme q10
Coenzyme Q10 (CoQ10) is a nutrient that occurs naturally in the body. CoQ10 is also in many foods we eat. CoQ10 acts as an antioxidant, which protects cells from damage and plays an important part in the metabolism.
Coenzyme Q10 is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is eaten in small amounts in meats and seafood. Coenzyme Q10 can also be made in a laboratory.
Coenzyme Q10 is most commonly used for conditions that affect the heart such as heart failure and fluid build up in the body (congestive heart failure or CHF), chest pain (angina), and high blood pressure. It is also used for preventing migraine headache, Parkinson disease, and many other conditions.
Coenzyme Q10 was first identified in 1957. The "Q10" refers to the chemical make-up of the substance.
What is coenzyme q10 used for
CoQ10 has been shown to help improve heart health and blood sugar regulation, assist in the prevention and treatment of cancer and reduce the frequency of migraines. It could also reduce the oxidative damage that leads to muscle fatigue, skin damage and brain and lung diseases.
What is coenzyme q10 in skincare
Q10 is a coenzyme found naturally in all body cells. It's vital for energy production to fulfil the skin's basic functions such as regeneration and repair. As our skin is the outermost layer of the body, it is constantly exposed to various external factors, including oxidative stress caused by the sun's UV rays. Plus, internal processes can cause the release of free radicals which cause further damage. So what is coenzyme Q10's role? Coenzyme Q10, or CoQ10, is released as an antioxidant to combat this oxidative stress, which is why it is so essential for smooth, healthy-looking skin.
What is coenzyme q10 made from
Coenzyme Q-10 (CoQ-10 or Ubiquinone) is a naturally occurring quinone that is found in most aerobic organisms from bacteria to mammals. It was first identified in 1940, and isolated from the mitochondria of the beef heart, in 1957.
What is coenzyme q10 for skin
CoQ10 is a powerful antioxidant that helps to defend skin from adverse effects of sun exposure that are caused by free radicals (unstable atoms that are able to damage skin cells). Reducing sun damage also helps to prevent sun induced signs of ageing. CoQ10 Supports the Production of Collagen & Elastin.
What is coenzyme q10 ubiquinone
Reduced CoQ10 is called ubiquinol. In the blood and lymphatic ducts, most of the body's CoQ10 is in the form of ubiquinol, where it acts as an antioxidant. It protects against oxidative damage of the LDL cholesterol (Low-Density Lipoprotein), the cholesterol form everyone is worried about.
The other form of CoQ10 is its oxidized form called ubiquinone. When CoQ10 was first discovered by Dr. Frederick Crane in 1957, it was actually the ubiquinone form he identified. All research from that point forward for the rest of the century centered only on ubiquinone. Can you spot the difference? Rotate the molecules and take a look at the quinone head. Compared to ubiquinol the ubiquinone form has two double bonds between oxygen and carbon and is missing two hydrogen atoms. Ubiquinone is a more stable form.
Inside the cell's mitochondria ubiquinone takes part in the cell's energy production. During this energy production CoQ10 is constantly switching from one form to the other several hundred times each second as each are a byproduct of the other, depending on whether it receives electrons (ubiquinone) or donates them (ubiquinol). You could compare this to performing in a play, where you play two different parts requiring costume changes for each character.
Ubiquinone is More Stable
In 2006, part of the CoQ10 industry started to market CoQ10 in the form of ubiquinol. The argument was that some people have difficulty converting ubiquinone to ubiquinol and therefore the idea was that you should take the missing form, which they at that point dubbed "active Q10." It later turned out that they were wrong about their concept. Scientists pointed out that the body can convert back and forth without any issues.
coenzyme q10 foods(what foods contain coenzyme q10)
The following foods contain CoQ10:
Organ meats: Heart, liver and kidney
Some muscle meats: Pork, beef and chicken
Fatty fish: Trout, herring, mackerel and sardine
Vegetables: Spinach, cauliflower and broccoli
Fruit: Oranges and strawberries
Legumes: Soybeans, lentils and peanuts
Nuts and seeds: Sesame seeds and pistachios
Oils: Soybean and canola oil
coenzyme q10 benefits
1. It May Help Treat Heart Failure
Heart failure is often a consequence of other heart conditions, such as coronary artery disease or high blood pressure. These conditions can lead to increased oxidative damage and inflammation of the veins and arteries. Heart failure occurs when these problems affect the heart to the point that it is unable to regularly contract, relax or pump blood through the body. To make matters worse, some treatments for heart failure have undesirable side effects, such as low blood pressure, while others could even further reduce CoQ10 levels. In a study of 420 people with heart failure, treatment with CoQ10 for two years improved their symptoms and reduced their risk of dying from heart problems. Also, another study treated 641 people with CoQ10 or a placebo for a year. At the end of the study, those in the CoQ10 group had been hospitalized less frequently for worsening heart failure and had fewer serious complications. It seems that treatment with CoQ10 could assist with restoring optimal levels of energy production, reduce oxidative damage and improve heart function, all of which can aid the treatment of heart failure.
2. It Could Help With Fertility
Female fertility decreases with age due to a decline in the number and quality of available eggs. CoQ10 is directly involved in this process. As you age, CoQ10 production slows, making the body less effective at protecting the eggs from oxidative damage. Supplementing with CoQ10 seems to help and may even reverse this age-related decline in egg quality and quantity. Similarly, male sperm is susceptible to the effects of oxidative damage, which may result in reduced sperm count, poor sperm quality and infertility. Several studies have concluded that supplementing with CoQ10 may improve sperm quality, activity and concentration by increasing antioxidant protection.
3. It Might Help Keep Your Skin Young
Your skin is the largest organ in your body, and it’s widely exposed to damaging agents that contribute to aging. These agents can be internal or external. Some internal damaging factors include cellular damage and hormonal imbalances. External factors include environmental agents, such as UV rays. Harmful elements can lead to reduced skin moisture and protection from environmental aggressors, as well as the thinning of the layers of the skin. Applying CoQ10 directly to the skin can reduce the damage from internal and external agents by increasing energy production in skin cells and promoting antioxidant protection. In fact, CoQ10 applied directly to the skin has been shown to reduce oxidative damage caused by UV rays and even decrease the depth of wrinkles. Lastly, people with low levels of CoQ10 seems to be more likely to develop skin cancer.
4. It Could Reduce Headaches
Abnormal mitochondrial function can lead to an increased calcium uptake by the cells, the excessive production of free radicals and decreased antioxidant protection. This can result in low energy in the brain cells and even migraines. Since CoQ10 lives mainly in the mitochondria of the cells, it has been shown to improve mitochondrial function and help decrease the inflammation that may occur during migraines. In fact, a study showed that supplementing with CoQ10 was three times more likely than a placebo to reduce the number of migraines in 42 people. Additionally, CoQ10 deficiency has been observed in people suffering from migraines. One larger study showed that 1,550 people with low CoQ10 levels experienced fewer and less severe headaches after treatment with CoQ10. What’s more, it seems that CoQ10 not only helps treat migraines but may also prevent them.
5. It Could Help With Exercise Performance
Oxidative stress can affect muscle function, and thus, exercise performance. Similarly, abnormal mitochondrial function can reduce muscle energy, making it hard for muscles to contract efficiently and sustain exercise. CoQ10 can help exercise performance by decreasing oxidative stress in the cells and improving mitochondrial functions. In fact, one study investigated the effects of CoQ10 on physical activity. Those supplementing with 1,200 mg of CoQ10 per day for 60 days showed decreased oxidative stress. Moreover, supplementing with CoQ10 can help increase power during exercise and reduce fatigue, both of which can improve exercise performance.
6. It Could Help With Diabetes
Oxidative stress can induce cell damage. This can result in metabolic diseases like diabetes. Abnormal mitochondrial function has also been linked to insulin resistance. CoQ10 has been shown to improve insulin sensitivity and regulate blood sugar levels. Supplementing with CoQ10 might also help increase CoQ10 concentrations in the blood by up to three times in people with diabetes who typically show low levels of this compound. Also, one study had people with type 2 diabetes supplement with CoQ10 for 12 weeks. Doing so significantly reduced fasting blood sugar levels and hemoglobin A1C, which is the average of blood sugar levels over the past two to three months. Lastly, CoQ10 might help prevent diabetes by stimulating the breakdown of fats and reducing the accumulation of fat cells that could lead to obesity or type 2 diabetes.
7. It Might Play a Role in Cancer Prevention
Oxidative stress is known to cause cell damage and affect their function. If your body is unable to effectively fight oxidative damage, the structure of your cells can become damaged, possibly increasing the risk of cancer. CoQ10 may protect cells from oxidative stress and promote cellular energy production, promoting their health and survival. Interestingly, cancer patients have been shown to have lower levels of CoQ10. Low levels of CoQ10 have been associated with up to a 53.3% higher risk of cancer and indicate a poor prognosis for various types of cancer. What’s more, one study also suggested that supplementing with CoQ10 may help reduce the chance of cancer recurrence.
8. It Is Good for the Brain
Mitochondria are the main energy generators of brain cells. Mitochondrial function tends to decrease with age. Total mitochondrial dysfunction can lead to the death of brain cells and diseases like Alzheimer’s and Parkinson’s. Unfortunately, the brain is very susceptible to oxidative damage due to its high fatty acid content and its high demand for oxygen. This oxidative damage enhances the production of harmful compounds that could affect memory, cognition and physical functions. CoQ10 may reduce these harmful compounds, possibly slowing the progression of Alzheimer’s and Parkinson’s disease.
9. CoQ10 Could Protect the Lungs
Of all your organs, your lungs have the most contact with oxygen. This makes them very susceptible to oxidative damage. Increased oxidative damage in the lungs and poor antioxidant protection, including low levels of CoQ10, can result in lung diseases like asthma and chronic obstructive pulmonary disease (COPD). Furthermore, it has been shown that people suffering from these conditions present lower levels of CoQ10. A study demonstrated that supplementing with CoQ10 reduced inflammation in individuals who had asthma, as well as their need for steroid medications to treat it. Another study showed improvements in exercise performance in those suffering from COPD. This was observed through better tissue oxygenation and heart rate after supplementing with CoQ10.
Coenzyme q10 skin
Benefits of CoQ10 for Skin
While naturally occurring CoQ10 can be digested for energy, it can do a number of things in skincare products too. In terms of skincare, it's usually in toners, moisturizers, and under eye creams, helping to even skin tone and reduce the appearance of fine lines.
Energizes cell activity: "This energy is needed to repair damage and make sure the skin cells are healthy," says Bullock. "Active skin cells get rid of toxins easily and can make better use of nutrients. When your skin ages, all these processes slow down, causing dull and sallow, wrinkled skin." CoQ10 can keep your cells active and energized, helping your cells rid themselves of toxins.
Reduce sun damage: "The skin is damaged by exposure to the sun's UV rays, which provides a source of free radicals, which can be damaging to the cells' DNA," says Pickens. "The potent antioxidant function of CoQ10 helps it to protect the skin at the molecular level from the damaging effects of the sun and from damage by free radicals." As Thomas explains, it works by "decreasing the collagen degradation of skin and interdicting the damage caused by photo-aging."
Even out skin tone: CoQ10 works to block tyrosinase, which helps with the production of melanin, which means that CoQ10 can help fade and prevent dark spots.1
Stimulate collagen and elastin production: "CoQ10 supports the bodies ability to produce collagen and elastin," says Bullock.
Replenishes skin cells: More energized skin cells means healthier skin cells. Adding CoQ10 to your skincare may allow your cells to better utilize other nutrients, leading to healthier skin overall.
Helps reduce damage of free radicals: Since CoQ10 aids in cell activity, it also means that your cells can be more efficient in flushing out toxins like free radicals and healing the damage they cause.
Helps soothe skin: While toxins are being flushed out, your skin is silently thanking you. CoQ10 works to help your cells remove what's irritating cells and your skin.
Reduces the appearance of wrinkles and fine lines: This ingredient helps your body produce collagen and elastin, which can reduce the appearance of fine lines.
Coenzyme q10 side effects
Side effects from CoQ10 seem to be rare and mild. They include diarrhea, nausea, and heartburn.
Risks. People with chronic diseases such as heart failure, kidney or liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure. Doses of more than 300 milligrams may affect liver enzyme levels.
Interactions. People taking blood thinners and thyroid medications as well as chemotherapy should check with their doctors before using CoQ10 supplements.
Coenzyme q10 dosage
Though 90–200 mg of CoQ10 per day is typically recommended, needs can vary depending on the person and condition being treated
COVID-19 ‒ a coronavirus disease, affected almost all countries in the world. It is a new virus disease, nobody has prior immunity to it, human population is prone to infections. In March 11 2020, WHO declared the pandemic status. The main symptoms include: fever, dry cough and fatigue. Virus proteins need mitochondrial energy for their own survival and replication. Upon viral infections, mitochondrial dynamics and metabolism can be modulated, which can influence the energy production in the host cells. Coenzyme Q10 is an integral component of mitochondrial respiratory chain and the key component of mitochondrial ATP production. The exact pathobiochemical mechanism of the disease is unknown. Modulated mitochondrial dynamics and metabolism with lower CoQ10 levels in viral infections leads us to the hypothesis that one of the main pathobiochemical effects of SARS-Cov-2 virus could be mitochondrial bioenergetics dysfunction with CoQ10 deficit leading to the reduction of its endogenous biosynthesis. The mechanism might be virus induced oxidative stress causing a mutation of one or more of the nine COQ genes, resulting in primary CoQ10 deficiency. New perspective for patients with COVID-19 may be supportive targeting therapy with coenzyme Q10 to increase the energy production, immunity and decrease oxidative stress (Fig. 1, Ref. 51). Keywords: COVID-19, virus, mitochondrial bioenergetics, coenzyme Q10, oxidative stress.
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