However, some people who are sensitive to the compound may experience side effects, such as diarrhea, headache, nausea and skin rashes.
It should be noted that taking CoQ10 close to bedtime may cause insomnia in some people, so it’s best to take it in the morning or afternoon.
CoQ10 supplements can interact with some common medications, including blood thinners, antidepressants and chemotherapy drugs. Consult your doctor before taking supplemental CoQ10.
As it’s fat-soluble, those supplementing with CoQ10 should keep in mind that it’s better absorbed when taken with a meal or snack that contains a fat source.
The standard dose for CoQ10 is generally 90mg for a low dose and 200mg for the higher dose, taken once daily with a meal due to its reliance on food for absorption. Dose-dependence is not commonly observed with CoQ10 supplementation and 90mg tends to be the best cost-effective dose.
There generally isn't too much of a therapeutic effect of CoQ10 supplementation (mostly taken with the 'just in case' mentality that pervades multivitamin supplementation), although for people who have previously experience a heart attack or damage to cardiac tissue as well as for people on statin therapy supplementation becomes much more important.
CoQ10 supplements can be either the oxidized form (ubiquinone) or reduced form (ubiquinol) as both forms seem pretty equally potent in increasing circulating levels of total CoQ10 in the body. 'Total CoQ10' refers to the sum of both forms, since CoQ10 can readily swap between forms as it acts in the body.
In general, studies concerning the benefits of CoQ10 have been inconsistent and/or inconclusive. The bulk of the research has concerned the following conditions:
Limited research indicates that CoQ10 might reduce the risk of some complications of heart surgery. It may also reduce heart damage from one type of cancer drug.
Coenzyme Q10 has not been proven to have any effect on cancer or its symptoms. Research on the effects of CoQ10 in preventing heart disease or treating heart failure has also been inconclusive.
The scientific evidence suggests that CoQ10 probably does not have a significant effect on blood pressure.
CoQ10 supplements may help prevent migraines, but the evidence for this remains limited.
Several studies have analyzed the effect of CoQ10 supplements on people with Parkinson’s disease. There were no adverse side effects, but there was also no significant improvement. People who were given the placebo and those given the supplement had the same reactions.
coq10 dosage for kidneys
We’re pretty used to hearing that CoQ10 is good for the heart, but little emphasis has been made to date on its kidney-protective effects.
Why should you care? Because the number of Americans that are affected by chronic kidney disease is growing.
In fact, approximately 13% of Americans have chronic kidney disease.1
This is a condition in which your kidneys are damaged and don’t filter waste properly. It can lead to problems such as cardiovascular and even bone disease.2
Kidney disease can progress to end-stage renal failure, an illness which can only be treated by dialysis or kidney transplantation. However, if chronic kidney disease is treated in time, kidney function can be preserved.
Research actually shows that CoQ10 supports kidney function in a few ways. Below, we’ll explore some of the research in further detail.
COQ10 GUARDS KIDNEYS AGAINST OXIDATIVE STRESS
Each day your kidneys produce about 8 cups of waste.3 This makes them extremely vulnerable to damage and oxidative stress.
Fortunately, nutrients like CoQ10 increase the production of kidney-protective antioxidants which combat free radicals.
CoQ10 increases serum levels of glutathione and catalase,4 which are both powerful kidney-protective antioxidants. In addition, it quenches production of superoxide,5 a damaging free radical.
Dialysis patients taking CoQ10 have been found to experience reduced oxidative stress.6
COQ10 PROTECTS AGAINST NEPHROTOXIC DRUGS
According to the CDC, 47.9% of Americans take at least one prescription medication.7 Depending on the drug, it could strain the kidneys and even cause irreversible damage.
Particularly offensive drugs include NSAIDS, certain antibiotics, acetaminophen, and lithium.
Research shows CoQ10 protects kidneys against various drugs including gentamicin,8 cisplatin,9 cyclosporine10 and simvastatin,11 a commonly used cholesterol-lowering drug. These drugs are known to often cause kidney damage.
COQ10 PREVENTS KIDNEY DYSFUNCTION
Doctors monitor kidney function by examining markers such as creatinine, BUN, albumin, and protein urine levels. The kidneys filter these compounds, and elevations may signal kidney damage or disease.
At the University of Tokyo, rats given CoQ10 (also known as ubiquinol) showed decreases in albumin levels after being subjected to a kidney-damaging procedure.5
The CoQ10 was found to be helpful in preserving kidney function. The researchers concluded, “Ubiquinol may be a candidate for the treatment of patients with kidney disease.”
Other studies show CoQ10 inhibits rises in urine protein levels12 and prevents elevations in creatinine when given along with alpha tocopherol.
People with chronic diseases such as heart failure, kidney or liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure.
Several clinical studies involving small numbers of people suggest that CoQ10 may lower blood pressure. However, it may take 4 to 12 weeks to see any change. In one analysis, after reviewing 12 clinical studies, researchers concluded that CoQ10 has the potential to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by 10 mm Hg, without significant side effects. More research with greater numbers of people is needed. DO NOT try to treat high blood pressure by yourself. See your provider for treatment.
Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination. Talk with your health provider. Coenzyme Q-10 seems to decrease blood pressure. Taking coenzyme Q-10 along with medications for high blood pressure might cause your blood pressure to go too low.
Regular monitoring of blood pressure is needed before any such judgments can be made. COQ10 should only be taken by adults 19 and older. Recommended dosages range from 30 mg to 200 mg daily, depending on the manufacturer. Soft gel capsules are thought to be absorbed better than other formulations.
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