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When to take 5htp after rolling?
Mar 25, 2021

When to take 5htp after rolling?

What does this mean for you, the responsible drug user? Well, it means that taking some antioxidants before and after your drug use can help prevent damage to your cells. Some popular antioxidants:


• Vitamin C: Also known as ascorbic acid, vitamin C is found in large amounts in citrus fruits like limes, oranges, and grapefruit. Besides being an antioxidant, vitamin C is important to the immune system. Vitamin C is a water soluble vitamin, so it mainly stays in the blood and other water-rich parts of cells like the cytoplasm.

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• Vitamin E: Nutritionally important, this vitamin is also a good antioxidant. Vitamin E is lipid (fat) soluble, which allows it to penetrate deeply into fatty tissues (including the brain) and even get inside of cell walls. In one experiment, mice fed a severely vitamin E deficient diet suffered serious neurotoxicity when given a large dose of MDMA, while mice on a normal diet were unharmed!


• Alpha-lipoic acid (ALA): ALA is an interesting antioxidant because it’s both lipid-soluble and water-soluble, allowing it to get virtually anywhere in the body. As a downside, ALA is more irritating to the stomach than E and C, limiting the amount that can be comfortably taken. ALA may also be broken down very quickly in the body.


• Melatonin: Traditionally sold as a sleep aid, melatonin is a very effective antioxidant on a per-weight basis, but at the doses recommended (as little as 0.25 mg) would be ineffective to use as an antioxidant. Since I don’t know what the consequences of high doses (100 mg or more) would be, I don’t recommend melatonin for this purpose.


• Green Tea, Grape Skin Extract, Grape Seed Extract, etc.: These substances have significant antioxidant properties, but are relatively unresearched. They may not be effectively transported into the brain.

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What should I take? How much?


For antioxidants, I recommend Vitamin C and E, period. They are actively transported into your brain (where they’re needed most), are generally well-tolerated, inexpensive, readily available, and fairly well researched (in the context of both general health and MDMA use.) Try 2-4 tablets/capsules of each within a few hours of taking MDMA and again after coming down. A little more the day after can’t hurt either.

When you take MDMA (aka, ecstasy or molly), the soaring euphoria you feel is actually your neurons opening their floodgates to allow stockpiled serotonin to pour out. With serotonin molecules floating around in the spaces between brain cells, they’re free for receptors on adjacent cells to grasp at, like a volley of baseballs into a field of gloves. The magic happens once the molecules are caught.


Serotonin is a signaling molecule. When enough receptors on a neuron manage to catch it, the neuron “fires,” kicking off an electrical chain reaction of signaling throughout the brain’s network of cells that eventually results in happiness, empathy, sociability, and a heightened sense of touch associated with rolling on MDMA. Eventually, the molecules are released, and they’re collected back by the cells they were first ejected from, where they’re broken down by an enzyme called monoamine oxidase. The wave of “happy” signaling ceases until a new trigger releases another flood of serotonin.

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When to take 5htp when rolling?

The jury is still out on this one due to lack of science.


It is generally regarded as a good idea to use 5-HTP in the weeks between rolls to replenish your serotonin levels. Daily use of 5-HTP (typically 200-300 mg) does not appear to cause any problems.

Some people swear by using 5-HTP to smooth out the comedown and reduce the ‘depression hangover’, but only if they haven't overdone MDMA in the first place. And only if they aren't on anti-depressants. Both OF those are red flags for 5-HTP.

5-HTP may protect the nerve cells from the neurotoxic effects of taking too much ecstasy.

On the other hand, there are several accounts saying that taking 5-HTP a few hours before MDMA can, paradoxically, ruin the roll by blocking the magic euphoria.

Personally, I would avoid 5-HTP while still feeling the effects of MDMA.


When you’re ‘up’ on MDMA, there's a lot of serotonin being released. This is all great, as your heart and mind glow like lovely campfires, and then your brain gradually mops it all up and you come back down. But if you add 5-HTP to the mix (or worse, an MAOI anti-depressant), it's like dropping a stick of dynamite onto your nice campfire. The brain can go haywire.

References:https://www.quora.com/Can-I-take-5HTP-after-taking-MDMA

https://thedea.org/mdma-ecstasy-molly-users-guide/mdma-molly-preloading-and-supplements/

https://www.inverse.com/mind-body/14216-5-htp-after-mdma-how-to-replenish-serotonin-after-rolling

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