Grifola frondosa belongs to basidiomycetes, hymenomycetes, achromydiomycetes, non-pleuromycetales, polyporaceae, genus frondosa, also known as tricholoma chestnut, polyporia conifera, and lotus, known as maitake in Japan. The fresh fruit-body aroma of grifola flower is rich in nutrition, essential amino acid content and physiological active substance -- grifola polysaccharide, which is one of the rare edible and medicinal fungi with great development value and wide application prospect.
In the past 20 years, researches on fungal polysaccharides as biological reaction regulators have been deeply carried out at home and abroad. Experts in the years of research at home and abroad through a large number of pharmacological analysis agree that maitake polysaccharide has obvious inhibiting tumor, anti-hiv, improve immune system function, regulate blood sugar, blood fat and cholesterol, blood pressure, etc, to prevent the formation of cancer cells and metastasis, AIDS, high blood pressure, obesity, diabetes and immune system function disorder have certain curative effect, and without any side effects.
As we all know, radiation can cause a variety of diseases and death, seeking natural, non-toxic side effects of drugs to prevent radiation caused by the disease has become a hot topic. It has been reported that poria cocos polysaccharide, ganoderma lucidum polysaccharide, hericium edodes polysaccharide and Grifola frondosa polysaccharide in fungal polysaccharides have anti-radiation effects.
The experimental results showed that grifola polysaccharide had significant anti-radiation effect, and the body weight, average survival time and 30-day survival rate of mice could be increased under the dose treatment of 200 mg•kg-1•d-1 and above.
Grifola frondosa polysaccharide had an obvious protective effect on the hematopoietic tissues of irradiated mice, and the content of DNA in bone marrow was increased. Grifola polysaccharide had an obvious protective effect on the radiation damage of mice, which may be related to the improvement of the immune function of the body, the enhancement of immune regulation and the protection of hematopoietic tissues.
The effect of radiation protection was positively correlated with dose to some extent.
Studies have shown that radiation damages the hematopoietic system and immune system, resulting in significantly reduced spleen weight, spleen cell number, and spleen lymphocyte transformation function. Apoptosis of bone marrow cells. Polysaccharides have the function of enhancing and regulating immunity, enhancing the formation of complement, and thus resisting radiation. Therefore, Grifola frondosa polysaccharide is a promising radioprotective drug, which is worthy of further study.