Diabetes is a common metabolic disorder. In addition to the injection of insulin, the main oral administration of sulfonylureas and diterpene hypoglycemic drugs, but there are many side effects, people are actively exploring the health care products that can treat diabetes and no toxic side effects . Ganoderma lucidum as a medicinal fungus is a health product first recognized by people. Its active ingredients are very rich, mainly ganoderma lucidum polysaccharides, triterpenoids, ganoderic acid, adenosine, of which Ganoderma lucidum polysaccharide is one of the most effective active ingredients, Ganoderma lucidum The pharmacological activity is mostly related to ganoderma lucidum polysaccharides
The study found that the mechanism of reducing the blood glucose concentration of the plant ganoderma lucidum polysaccharides is mainly divided into two aspects, one is the impact on insulin levels. Insulin is the only hypoglycemic hormone in the body. Its role is mainly to promote glucose in human blood to enter into tissue cells, promote the synthesis of glycogen, inhibit the decomposition of glycogen, and reduce gluconeogenesis. Insulin can inhibit the conversion of non-sugar substances (such as fats, proteins, etc.) into glucose and glycogen, and can also promote excess glucose into lipid defense, which can promote fat synthesis and lower blood lipids. In addition, insulin can also promote protein synthesis and inhibition. Protein decomposition and other effects.
Another aspect is the effect on the activity of sugar-metabolizing enzymes. Ganoderma lucidum polysaccharides can act on enzymes that metabolize sugars, such as glucokinase. Glucokinase is the first rate-limiting enzyme for glucose aerobic oxidation of hepatocytes. It promotes the phosphorylation of glucose, produces glucose 6-phosphate, promotes the utilization of glucose and the synthesis of hepatic glycogen. Studies have shown that Ganoderma lucidum polysaccharides can increase the activity of glucokinase and directly strengthen the aerobic oxidation process of glucose in the body, thereby reducing blood glucose concentration.
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