Aging is inevitable and natural process that marks time passing us by, leaving subtle yet irreversible effects on our body. Anti-Aging products have gained increasing interest as society ages; global antiaging market expected to reach 18B USD by 2030.
Aging is an intricate interplay of cell dynamics. Cell health and vitality impact the entire health of an organism; therefore, supporting it at its source is an integral component of anti-ageing. Spermidine has become popular as an amino-acid that could delay aging; in addition, spermidine also supports autophagy of cells as well as mitochondrial function (where energy production occurs).
what is spermidine?
In 1678, Dutch scientist Antonie van Leeuwenhoek first identified crystals found in human semen. Over 250 years later, Rosenheim illuminated their structure. Spermidine, an abundant polyamine present throughout our bodies' cells, plays an essential role in cell renewal.
Spermidine, a biogenic amine produced from putrescine metabolism, plays an essential role in cell division and proliferation. Its association with body odor makes spermidine highly prevalent among mammals; food such as wheat germ, soya, aged cheese and mushrooms may also contain high quantities. Commensal bacteria in humans can produce it from putrescine and arginine; while mammalian cells also utilize putrescine production from this pathway in producing polyamine spermidine.
Humans typically have circulating spermidine levels that fall in the micromolar range, likely as a result of diet's impact on concentration of spermidine levels; individual variations exist and vary widely. As we age, cell levels decrease; adding exogenous spermidine may slow or reverse these age-related changes.
what foods contain spermidine?
Spermidine, present in all plant-derived foods, is generally the predominant polyamine. The food categories with the highest contents of spermidine and spermine are cereals, legumes and soy derivatives.
Food Sources of Spermidine
Wheat germ.
Soybeans.
Green peas.
Cheddar cheese (and other mature cheeses)
Mushrooms.
Pears.
Chicken Liver.
Beef.
does chlorella contain spermidine?
Yes - and in impressive numbers. While wheat germ, soybeans, or pumpkin seeds are valued as natural sources of spermidine, chlorella contains around 630 - 930 mg/kg, many times their amount, and is therefore a particularly rich, plant-based source.
How does Spermidine work for anti-aging?
Age cannot be stopped, but lifestyle changes, genetic and biological interventions, drugs and supplements can still alter its progression. One such compound that can slow aging is Spermidine; abnormal changes to this intracellular concentration has been linked with disease and aging as we get older and its presence declines within cells; supplementing exogenous spermidine can extend lifespans in yeast, nematodes and flies while diets high in Spermidine have also shown to extend lives; autophagy appears to be its main mechanism through which this spermidine slowing its path toward slowing aging.
(1) Autophagy can help save autophagy.
Autophagy is the natural cleaning process of cells. This intricate system transports damaged cytoplasmic elements to lysosomes for disposal. Autophagy keeps our bodies healthy while simultaneously guarding us against disease.
Aging promotes the accumulation and breakdown of damaged cellular elements (including proteins and organelles) while diminishing cells' abilities to degrade them, necessitating autophagy as a protective mechanism against further cell damage and thus prolonging life span. Autophagy thus plays an essential role in anti-ageing prevention and life extension by serving as a preventative mechanism against further cell degradation. Autophagy is an anti-ageing mechanism. Decreased autophagy accelerates aging through increased oxidative damage. These factors lead to an uncontrolled accumulation of proteins, reduced energy production by mitochondrial functions, and other biochemical processes associated with accelerated cell aging. Such issues can affect any area of human tissue - but particularly brain tissue which is one of the most metabolically active.
Autophagy decreases with age and is responsible for sarcopenia - a progressive decline in muscle mass and strength as we age. Spermidine induces autophagy in various organs such as mice' hearts, livers and muscles as well as aged yeast, worms, flies, cultured mammalian cells as well as cultured yeast, worms and flies as well as cultured mammalian cells - modulating expression levels related to autophagy genes is how Spermidine triggers autophagy processes.
(2) Inflammation
Inflammation has both beneficial and deleterious effects on immunity, helping the body resist pathogen invasion while simultaneously disrupting balance within the body and leading to disease. Over-inflammation or "inflammatory aging," as it's more commonly known, is an influential risk factor of aging and affects mitochondrial function due to stress caused by prooxidants and free radicals. Reports indicate that supplementing with spermidine helps to lower chronic inflammation through its ability to lower TNF-a levels and thus limiting inflammation and cardiovascular dysfunction. Spermidine's biological function of protecting DNA replication from oxidative stress has also been suggested as one possible mechanism.
spermidine benefits
(1) Cardiovascular diseases
Spermidine is a powerful antioxidant that protects the heart from aging. It improves mitochondrial function, left ventricle elasticity and diastolic functions in aged mice. These findings are confirmed in human studies: In the Bruneck cohort dietary intake of spermidine or a combination of both spermidine, and spermine was negatively related to the incidence of cardiovascular diseases and deaths. The results of a cross-sectional meta-analysis of the nutritional polyamine content in relation to mortality from cardiovascular disease were based on publicly available data for 48 Western countries. Spermidine and spermine intakes were found to be negatively correlated.
(2) Neuroprotection
Spermidine can have neuroprotective effects when administered in vivo. In Drosophila spermidine can be fed to prevent age-induced motor impairment and memory impairment in an autophagy dependent manner. In mice, spermidine has been shown to promote retinal ganglion cells survival and optic nerve regeneration after an optic nerve injury. It can also slow down retinal degeneration when used in a model of normal-tension eye disease. Spermidine is also reported to help improve dementia caused by ageing. It can reduce mitochondrial dysfunction and maintain neuronal power, as well as prevent inflammation and neuronal apoptosis.
Other
Hair growth and hair loss is a more exotic application of spermidine. In vitro experiments on epithelial cells of the human scalp and hair follicles revealed that spermidine had a positive effect on hair growth as well as the regulation of these cells. In a 90-day study, spermidine was shown to promote hair growth and resistance among human subjects.
Chronic diseases, such as cancer, diabetes, and cardiovascular diseases, are on the rise. Healthy aging interventions would be a powerful way to reduce human diseases that have a wide socioeconomic impact. The spermidine industry has grown rapidly since the publication of first research results. This growth offers business opportunities to different industries. The demand for dietary products containing spermidine is increasing as people become more aware of their health. Cosmetics companies are also exploring spermidine's skin rejuvenation effects, which adds a whole new dimension to the market. The pharmaceutical industry is also exploring spermidine's role in different therapeutic areas. The food industry also incorporates spermidine rich ingredients into functional foods to leverage the health-promoting qualities of the compound.
where can i buy spermidine?
Undersun biomedtech has working on the R&D of spermidine for many years and we could supply the following products:
-Wheat Germ Extract
-Spermidine powder
-Spermidine hydrochloride
-Spermidine compound solutions
Just feel free to contact us or submit your inquiry from the bottom form.
References:
Frank Madeo, Tobias Eisenberg, Federico Pietrocola and Guido Kroemer. (2018). Spermidine in health and disease.Science, 359 (6374), eaan2788.
