OPC’s are also called “Pycnogenol”(a registered trade name) when they are derived from pine bark. The grape seed extract is slightly more potent and less expensive. You will see the terms Pycnogenol, OPC’s, and grape seed extract used interchangeably.
Pycnogenol is a compound of natural chemicals. It comes from the bark of a European pine tree.Pycnogenol is thought to be an antioxidant that helps protect cells from damage.
Pycnogenol is the registered trademark name for a French formula. The active ingredients in pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark.
Grapes -- along with their leaves and sap -- have been traditional treatments in Europe for thousands of years. Grape seed extract is derived from the ground-up seeds of red wine grapes. Although fairly new to the U.S., grape seed extract is now used to treat a number of diseases.
Aromatase is the enzyme that converts androgen to estrogen. It is expressed at higher levels in breast cancer tissues than normal breast tissues. Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown in our laboratory to be potent inhibitors of aromatase. In this study, GSE was found to inhibit aromatase activity in a dose-dependent manner and reduce androgen-dependent tumor growth in an aromatase-transfected MCF-7 (MCF-7aro) breast cancer xenograft model, agreeing with our previous findings. We have also examined the effect of GSE on aromatase expression. Reverse transcription-PCR experiments showed that treatment with 60 mug/mL of GSE suppressed the levels of exon I.3-, exon PII-, and exon I.6-containing aromatase mRNAs in MCF-7 and SK-BR-3 cells.
The levels of exon I.1-containing mRNA, however, did not change with GSE treatment. Transient transfection experiments with luciferase-aromatase promoter I.3/II or I.4 reporter vectors showed the suppression of the promoter activity in a dose-dependent manner. The GSE treatment also led to the down-regulation of two transcription factors, cyclic AMP-responsive element binding protein-1 (CREB-1) and glucocorticoid receptor (GR). CREB-1 and GR are known to up-regulate aromatase gene expression through promoters I.3/II and I.4, respectively. We believe that these results are exciting in that they show GSE to be potentially useful in the prevention/treatment of hormone-dependent breast cancer through the inhibition of aromatase activity as well as its expression.
Grapefruit Seed Extract
Grapefruit is a fruit that provide multiple health benefits. This citrus fruit is a great source of vitamin C, fiber, potassium, pectin, antioxidants, and other nutrients. Grapefruit juice is used to battle high cholesterol and hardening of the arteries, known as atherosclerosis, as well as skin issues, weight loss and obesity.
However, grapefruit seed extract has been used as medicine for many years as this incredible product can efficiently treat bacterial, viral, and fungal infections including yeast infections. Additionally, grapefruit seed extract is often used as an ear or nasal rinse for preventing and treating infections. Grapefruit seed extract is generally considered safe.
Grape Seed Extract
Grapes are known as a healthy fruit but its seeds offer some pretty special benefits. Grape seed extract is derived from seeds of red wine grapes and can be used to treat a number of diseases, particularly cardiovascular conditions, due to its high level of antioxidants.
Grape seed extract may help regulate poor blood circulation, reduce high cholesterol, minimize swelling caused by injury, and speed up wound healing. Grape seed extract is also generally considered safe.
For bulk Grape Seed Extract powder, please contact us at email: [email protected]