est-selling dietary supplement
Cranberry-derived dietary supplements and beverages are widely used to prevent and treat recurrent urinary tract infections. In the United States, cranberry is the third-best-selling botanical dietary supplement, and in mainstream retail outlets in 2017 (pharmacies, The sales of grocery stores, etc.) reached $68.12 million.
The ingredients of various cranberry supplements on the market vary widely, especially for proanthocyanidins (PACs). Proanthocyanidins are considered to be one of the most active ingredients in cranberry and are responsible for preventing the adhesion of bacteria in the urethra. In commercial cranberry extracts, PAC concentrations range from 0.8% to 24%, and PAC levels in most products range from 0.8% to 1.5%. Depending on the concentration of PAC, bulk cranberry products are priced at $50-$600 per kilogram in 2017.
Low-cost PACs obtained from other plant sources, such as peanuts (peanut skin) or grapes (grape seeds), are used by some unscrupulous suppliers to dilute or replace cranberry PACs for high economic benefits. Other known cranberry inclusions also include anthocyanin-rich materials extracted from other low cost materials.
Anthocyanins range in color from red to blue, and anthocyanin-rich extracts are used to mimic the color of the cranberry extract. A summary of these cranberry adulteration methods was published in the December 2017 issue of BAPP's Cranberry Plant Adulteration Prevention Bulletin.
How to evaluate adulteration
The new LGD was written by Dr. John H. Cardellina II, a renowned natural product chemistry and analysis expert, and Dr. Stefan Gafner, Chief Scientific Officer of the American Botanical Committee (ABC) and BAPP Technical Director. LGD evaluated the effectiveness of published analytical methods for detecting adulteration of cranberry products and summarized the main advantages and disadvantages of each method for its suitability in quality control laboratories.
The document also details the chemical composition of the cranberry, the species that may be confused, and the known adulterants. TLD was peer reviewed by 20 international experts from academia, government, third-party contract analysis laboratories and the herbal medicine industry.
Stefan Gafne explained that the variability of the production process, and the composition of the corresponding commercial cranberry ingredients, makes it challenging to find an analytical method that can detect all types of adulteration. Depending on the product specifications, a test method may be required to clearly identify the cranberry extract.
BAPP founder Mark Blumenthal said that this new laboratory guidance document provides much-needed resources for industry and third-party analytical laboratories to ensure that the analytical methods used to detect adulteration are effective and appropriate to regulate global vines. Bilberry extract market.
Blumenthal added that the old analytical method may not accurately detect the type of adulterated chemical components used in cranberry on the market, and any company that relies on some old testing methods may “approve” adulterated materials.
Researchers point out that interest and efforts to develop appropriate methods to ensure the authenticity and purity of cranberry products are proliferating, whether it is juice or extract. In the near future, there may be more ways to be discovered, and BAPP will also know the progress of stakeholders and the public as soon as possible.