Cassia Seed Benefits
Sep 23, 2021

Cassia seed is a frequently used traditional Chinese herb first documented in Sheng Nong’s Herbal Classic for its effects of liver detoxification, vision improvement, dispelling of the wind-evil, dissipating heat, and bowel relaxation. Modern pharmacological studies have indicated that the cassia seed had noticeable pharmacological effects, such as reduction in the blood lipid and blood pressure level as well as inhibition of lipid oxidation [11, 12]. Fu et al. [13] indicated that the cassia seed extract could effectively alleviate myocardial ischemia/reperfusion injury in diabetic rats and its mechanism may be related to the lipid-lowering effect and Akt and ERK1/2 signaling pathway activation. However, to the best of our knowledge, no report has yet proven whether the cassia seed extract reduces insulin resistance in the skeletal muscle. This study aimed to observe the hypoglycemic effect of cassia seed extract in rats with type 2 diabetes and its effect on reducing insulin resistance in the skeletal muscle. The report is shown in the following sections.

Materials and methods

Laboratory animals

A total of 50 male SD rats (SPF grade) aged 6 weeks, weighing 180–200 g were purchased from the Animal Experimental Center. Under the condition of alternating light and dark, all the rats were raised in separate cages of the animal house at a temperature of 22 °C ± 5 °C and humidity of 50% ± 10%. These rats were given ad libitum access to food and water, and were selected for this experiment after they were fed adaptively for 1 week.

Cassia Seed Extract-2

Laboratory reagents

Cassia seed extract was provided by the Nanjing Bangnuo Biotechnology Co., Ltd. Streptozotocin (STZ) was provided by Sigma Company. Rabbit P-LKB1, P-AMPKa12, AMPKa2, P-AMPKa2, and GLUT4 antibodies; anti-GAPDH rabbit antibody; protease inhibitor; and phosphatase inhibitor were provided by the American Sigma Company. The ECL kit was provided by Beijing Zhongshan Biotechnology Co., Ltd. The TaKaRa RNA PCR kit was provided by Takara Biotechnology (Dalian) Co., Ltd. The detection kit for glycogen in the skeletal muscle was provided by the Nanjing Jiancheng Bioengineering Institute, and the insulin kit was provided by Dalian Beyotime Biotechnology Institute.


Building and grouping of the animal model

A total of 10 rats were randomly selected and included in the normal group to be fed a normal diet. The other 40 rats were selected for the modeling of type 2 diabetes rats using the method described in the literature. The rats were fed a high-fat and high-sugar diet (fat 41%, protein 17%, carbohydrate 42%) for 8 weeks, followed by fasting of 12 h. Next, 35 mg/kg streptozotocin (STZ) was injected intraperitoneally once. Blood samples were collected from the caudal vein to detect the fasting blood glucose of rats 3 days after the injection. A fasting blood glucose level of ≥ 16.7 mmol/L indicated successful modeling of type 2 diabetes rats. These 40 rats that were modeled successfully were randomly divided into the model group, high-dose group of cassia seed extract, middle-dose group of cassia seed extract, and low-dose group of cassia seed extract.

Cassia Seed for Weight Loss

Given the fact that these miraculous seeds have a longstanding tradition as ingredients in alternative medicine and tea, and because of its numerous health benefits, we choose them as ingredients in our Teatox products. When it comes to weight loss, the Cassia seeds are one of the most effective natural ingredients a detoxing tea can contain. They have the ability to maintain the health of your digestive system, all while helping you get rid of unwanted toxins. Alongside the other natural ingredients found in our detox tea, the Cassia seed is the perfect ally for all women who want to lose weight the healthy way, and create the perfect setting for improving their lifestyle and undergoing a much healthier diet.

The seeds are also an exceptional tonic for the bowel, liver and kidney. As for the external use of the Cassia seed, it can treat red or itchy eyes and has been known to also alleviate discomfort in the case of light-sensitive eyes.

Cassia Seed how to use

Cassia Seed how to use

Cassia seeds (or Semen Cassiae) is a widely used Chinese medicinal herb. It is used primarily to clear heat in the body and is often prescribed for people with blood shot, irritated, swollen or teary eyes. The cooling effect means that it can be helpful to aid sleep and is sometimes used to aid with constipation.

To use these seeds simply throw in soups while cooking or simmer with hot water for a few minutes (blended with other teas and herbs of your choice).

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