Ubiquinol vs CoQ10,Ubiquinol versus CoQ10
Only after you take CoQ10 (ubiquinone) does your body convert it to the active form, ubiquinol. Taking 100 mg of ubiquinol (sometimes labeled as CoQH-10 or CoQH2-10) compared to 100 mg of CoQ10, may yield a bit more active compound in your body. In short, you may be able to take a little less ubiquinol than CoQ10 to get the same result.
However, more important than whether you take CoQ10 or ubiquinol is that fact that both are fat-soluble compounds, so to significantly improve their absorption, it is important to take them with a fatty meal or in a formula that includes solubility enhancers.
More information about CoQ10 and ubiquinol and their solubility-enhanced formulas is found in the CoQ10 and Ubiquinol Supplements Review, which includes our test results and quality ratings of dozens of products, as well as ingredient and price comparisons.
Ubiquinol vs CoQ10 fertility
Myth 1: There is no link between CoQ10 and fertility.
Fact: CoQ10 and fertility go hand-in-hand.
Ovulation is an energy-intense process. A woman’s eggs (oocytes) are cells, and the mitochondria are responsible for energy production within the cell. The human egg contains more mitochondria than any other cell.
CoQ10 plays a crucial role in energy production inside the mitochondria. As men and women people age, production of CoQ10 decreases. CoQ10 levels are highest during the first 20 years of life, after which they begin to decline.
For this reason, an older women’s eggs become less efficient at producing energy with age.
Studies indicate that CoQ10 may help support fertility and a healthy pregnancy. CoQ10 promotes egg quality in older women.
Myth 2: CoQ10 only helps female fertility.
Fact: There’s a connection between CoQ10 and male fertility, too.
Several factors that contribute to male fertility. Perhaps one of the most damaging can be the presence of free radicals.
It takes approximately three months for fully mature sperm to form. During that time, free radicals can cause damage to the sperm by attacking and destroying the membrane that surrounds sperm cells. They can also severely damage DNA, causing errors in the genetic information carried by the sperm.
CoQ10 is a powerful antioxidant. Antioxidants like CoQ10 work by protecting cells from damaging oxidative reactions caused by free radicals. Studies have shown that CoQ10 may support healthy sperm motility (the ability for sperm to swim), sperm density, motility, and morphology.
Myth 3. CoQ10 is only good for heart health.
Fact: CoQ10 works for all cells in your body.
The benefits of CoQ10 for supporting heart health are well-documented. However, if you know how CoQ10 works in general, you can see that it may be beneficial for almost every cell in your body.
Cells are the building blocks of life, and CoQ10 plays a significant role in cell function. When we eat food, those nutrients must be converted into a form of energy that cells can use. This conversion process is called cellular respiration. A majority of cellular respiration happens within the mitochondria, an organelle often called the “powerhouse” of the cell.
Cellular respiration involves several different complex processes to extract energy from nutrients. One of these processes is called the electron transport chain (ETC). The ETC relies heavily on CoQ10 to help carry electrons through its different stages. If CoQ10 levels are low, cells produce energy less efficiently.
In addition to helping in the ETC, CoQ10 is a powerful antioxidant. Antioxidants are substances that protect cells from damaging reactions. Highly reactive molecules, or free radicals, can cause lots of damage to the cell.
As an antioxidant, CoQ10 can help neutralize free radicals and support the health of all cells in your body.
Myth 4: The best form of CoQ10 for fertility is ubiquinol.
Fact: It’s not the form of CoQ10 that matters, it’s the way it’s prepared.
Because there is a lot of conflicting information available, many people want to know which is the preferred form of CoQ10 for fertility – ubiquinone or ubiquinol?
Ubiquinone is the oxidized form of Coenzyme Q10, while ubiquinol is the reduced form. Both forms exist within our bodies, and we can convert between the two depending on our body’s needs.
CoQ10 supplements are available in many forms, including softgels, capsules, tablets, and oral sprays. However, most CoQ10 supplements (standard ubiquinone or ubiquinol) are not very well absorbed in the body, even when taken with food.
Enhanced Absorption Technology
Fortunately, there are some CoQ10 supplements available that use an enhanced absorption delivery system. This type of formulation improves the bioavailability of CoQ10 by up to 600%.
In a 2009 study conducted by Liu, et al., participants received a single dose of 125 mg of ubiquinone formulated with VESIsorb® (an enhanced absorption delivery system). These participants demonstrated CoQ10 blood levels that were 3-6 times higher than those taking the same dose of other oil-based ubiquinone products.
Those taking ubiquinone with VESIsorb achieved peak CoQ10 blood levels of 7.0 mcg/mL. Participants taking other oil-based/solubilized products only reached peak blood levels of roughly 2 – 3.5 mcg/mL.
Myth 5: The CoQ10 fertility dosage is 600 mg for women.
Fact: Dosing varies depending on the type of CoQ10 you take and what you’re taking it for.
There is little human research looking at CoQ10 for egg quality. Therefore, the medical community has yet to reach a consensus about the recommended dosage for women. However, one study used a dose of 600 mg, taken once a day for two months. Therefore, most fertility specialists will recommend this dose for their female patients.
However, this study used standard oil-based ubiquinone. Remember the pesky problem of CoQ10 being hard to absorb? That comes into play when calculating the amount you should take to support healthy egg quality in women.
If you are taking a product formulated with enhanced absorption technology you can take a lower dose since it results in a 3-6 times higher “absorbed dose.”
Dr. Richard Sherbahn of the Advanced Fertility Center of Chicago writes that the recommended dose of CoQ10 varies between 50 mg and 600 mg a day, divided into multiple doses. He further explains that CoQ10 is most often recommended at doses of 100 to 300 mg a day and that up to 1,200 mg a day is considered safe.
Myth 6: CoQ10 is a vitamin.
Fact: CoQ10 is “vitamin-like.”
CoQ10 is a member of the ubiquinone family of compounds. It is a fat-soluble, vitamin-like compound that is naturally produced by the human body.
It is referred to as a “vitamin-like” compound because the body can make it on its own. Vitamins, by definition, cannot be made by the body. They must be obtained through the diet or nutritional supplements.
The name ubiquinone refers to the fact that ubiquinones, including CoQ10, have a “ubiquitous” presence in living organisms. In other words, virtually all cells in the human body contain CoQ10. Because it is so abundant in the body, CoQ10 is an essential compound for cell function.
Coenzyme Q10 concentrations are highest in organs with high rates of metabolism, such as the heart, kidneys, and liver.
Myth 7: You can get all the CoQ10 you need through your diet.
Fact: You could, but you’d have to eat a lot of organ meat.
While our bodies naturally make CoQ10, you can also get it by eating certain foods. Food sources of coenzyme Q10 include fatty fish, organ meats such as liver, and whole grains.
Because CoQ10 concentrations are highest in the heart, kidneys, and liver, the best dietary sources of CoQ10 are organ meats. For example, pork heart contains approximately 127 micrograms of CoQ10 per gram of meat. Coming in second, beef heart contains about 113 micrograms of CoQ10 per gram of meat.
To compare that to other dietary sources of CoQ10, canned tuna contains only 16 micrograms of CoQ10 per gram of tuna. Wheat germ has a mere six micrograms of CoQ10 per gram of wheat germ. Be aware, cooking coenzyme Q10 containing foods reduces the amount of CoQ10 by 14-32%.
Myth 8: I should continue taking CoQ10 throughout my pregnancy.
Fact: For most women, CoQ10 will not have additional benefits during pregnancy.
As explained earlier in this article, CoQ10 may support healthy egg quality and fertility. Although there is no reason to think that CoQ10 is unsafe during pregnancy, most women do not need to continue it once pregnant.
Ubiquinol vs CoQ10 Benefits
Antioxidant properties of ubiquinol
Ubiquinol is one of the most powerful known antioxidants, defending cells from the potentially harmful overaccumulation of free radicals and oxidative stress. Free radicals are created when the body converts food into energy. They can damage cells, protein, DNA. The antioxidant properties in the active form of CoQ10 can help to minimise these negative side effects of energy production.
Antioxidants can support the following areas of health:
Teeth & gums
Bones & muscles
Ubiquinol can help you replenish natural cellular energy that is used up through daily activity and which declines naturally as you age. Although Ubiquinol helps to sustain natural energy levels, it is not a “quick fix” for people who feel they need an energy boost when showing signs of fatigue. You won’t experience a buzz like you may get from caffeine or a chocolate fix.Rather, Ubiquinol works slowly over time to support and maintain natural energy production inside the cells of your organs, such as your heart and lungs, helping them to function at optimal levels.As your cellular energy levels improve with Ubiquinol, you’ll be able to avoid mid-afternoon fatigue and get through your day in a more productive way.
Ubiquinol vs CoQ10 absorption
This greater bioavailability was also shown for chronic intake. In a crossover, comparative study in 12 healthy subjects, uptake of Ubiquinol and coenzyme Q10 (200 mg/d) were compared after four weeks of supplementation. Ubiquinol was absorbed over two times as well as ubiquinone in direct comparison (P<0.005). When comparing final plasma concentrations, Ubiquinol was absorbed 1.7 times more than CoQ10 (4.3 µg/ml vs. 2.5 µg/mL), or 70% better.2 A possible mechanism for this is increased micellarization in the gut, because the reduced nature of Ubiquinol facilitates micelle formation, a necessary step in absorption in the small intestine.3
The amount of absorption will vary based on a person's age and state of health, but in every published comparative study that has been done, Ubiquinol has consistently been much better absorbed than coenzyme Q10 and replenishes the plasma concentration.1,2,4-8
Along with bioavailability, transportability in the blood to the sites of use is a key factor in efficacy. Ubiquinol is transported in the blood by attaching to lipid low density lipoprotein cholesterol (LDL cholesterol) particles. If coenzyme Q10 is ingested, the body quickly transforms it into Ubiquinol via an enzymatic reaction, making it the form that is most preferred by the body for transport in the blood.6 Some people cannot perform that transition very efficiently, and therefore receive very little benefit if they take coenzyme Q10 as opposed to Ubiquinol (look for a future blog on this topic!). However, in a healthy adult, more than 95% of the total coenzyme Q10 in the blood is in the Ubiquinol form.9-11 A major portion of CoQ10 in tissues is also in the reduced form as Ubiquinol.
Ubiquinol vs CoQ10 dose,Ubiquinol dosage(How much ubiquinol should I take daily)
Though 90–200 mg of CoQ10 per day is typically recommended, needs can vary depending on the person and condition being treated (8Trusted Source).
Statin Medication Use
Statins are a group of medications that are used to lower high blood levels of cholesterol or triglycerides to prevent heart disease (9Trusted Source).
Though these drugs are generally well tolerated, they can cause adverse side effects, such as serious muscle injury and liver damage.
Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues.
Research has shown that supplementing with CoQ10 reduces muscle pain in those taking statin medications.
A study in 50 people taking statin medications found that a dose of 100 mg of CoQ10 per day for 30 days effectively reduced statin-related muscle pain in 75% of patients (11Trusted Source).
However, other studies have shown no effect, emphasizing the need for more research on this topic (12Trusted Source).
For people taking statin medications, the typical dosage recommendation for CoQ10 is 30–200 mg per day (13Trusted Source).
Those with heart conditions, such as heart failure and angina, may benefit from taking a CoQ10 supplement.
A review of 13 studies in people with heart failure found that 100 mg of CoQ10 per day for 12 weeks improved blood flow from the heart (14Trusted Source).
Plus, supplementing has been shown to reduce the number of hospital visits and the risk of dying from heart-related issues in individuals with heart failure (15Trusted Source).
CoQ10 is also effective in reducing the pain associated with angina, which is chest pain caused by your heart muscle not getting enough oxygen (16Trusted Source).
What’s more, the supplement may reduce heart disease risk factors, such as by lowering “bad” LDL cholesterol (17Trusted Source).
For people with heart failure or angina, the typical dosage recommendation for CoQ10 is 60–300 mg per day (18Trusted Source).
When used alone or in combination with other nutrients, such as magnesium and riboflavin, CoQ10 has been shown to improve migraine symptoms.
It has also been found to ease headaches by reducing oxidative stress and free radical production, which may otherwise trigger migraines.
CoQ10 decreases inflammation in your body and improves mitochondrial function, which helps reduce migraine-associated pain (19Trusted Source).
A three-month study in 45 women demonstrated that those treated with 400 mg of CoQ10 per day experienced significant reductions in the frequency, severity and duration of migraines, compared to a placebo group (20Trusted Source).
For treating migraines, the typical dosage recommendation for CoQ10 is 300–400 mg per day (21Trusted Source).
As mentioned above, CoQ10 levels naturally deplete with age.
Thankfully, supplements can raise your levels of CoQ10 and may even improve your overall quality of life.
Older adults with higher blood levels of CoQ10 tend to be more physically active and have lower levels of oxidative stress, which may help prevent heart disease and cognitive decline.
CoQ10 supplements have been shown to improve muscle strength, vitality and physical performance in older adults (23Trusted Source).
To counteract the age-related depletion of CoQ10, it’s recommended to take 100–200 mg per day (24Trusted Source).
Both oxidative stress and mitochondrial dysfunction have been linked to the onset and progression of diabetes and diabetes-related complications (25Trusted Source).
What’s more, those with diabetes may have lower levels of CoQ10, and certain anti-diabetic drugs may further deplete body stores of this important substance (26Trusted Source).
Studies show that supplementing with CoQ10 helps reduce the production of free radicals, which are unstable molecules that can harm your health if their numbers get too high.
CoQ10 also helps improve insulin resistance and regulate blood sugar levels in people with diabetes.
A 12-week study in 50 people with diabetes found that those who received 100 mg of CoQ10 per day had significant reductions in blood sugar, markers of oxidative stress and insulin resistance, compared to the control group (27Trusted Source).
Doses of 100–300 mg of CoQ10 per day appear to improve diabetes symptoms (28Trusted Source).
Oxidative damage is one of the main causes of both male and female infertility by negatively affecting sperm and egg quality (29Trusted Source, 30Trusted Source).
For example, oxidative stress can cause damage to sperm DNA, potentially resulting in male infertility or recurrent pregnancy loss (31Trusted Source).
Research has found that dietary antioxidants — including CoQ10 — may help reduce oxidative stress and improve fertility in both men and women.
Supplementing with 200–300 mg per day of CoQ10 has been shown to improve sperm concentration, density and motility in men with infertility (32Trusted Source).
Similarly, these supplements may improve female fertility by stimulating ovarian response and help slow ovarian aging (33Trusted Source).
CoQ10 doses of 100–600 mg have been shown to help boost fertility.
As CoQ10 is involved in the production of energy, it’s a popular supplement amongst athletes and those looking to boost physical performance.
CoQ10 supplements help reduce the inflammation associated with heavy exercise and may even speed recovery (35Trusted Source).
A 6-week study in 100 German athletes found that those who supplemented with 300 mg of CoQ10 daily experienced significant improvements in physical performance — measured as power output — compared to a placebo group (36Trusted Source).
CoQ10 has also been shown to reduce fatigue and increase muscle power in non-athletes.
Doses of 300 mg per day appear to be most effective in boosting athletic performance in research studies.
Dosage recommendations for CoQ10 vary depending on individual needs and goals. Speak with your doctor to determine the right dose for you.
Ubiquinol vs CoQ10 for dogs
As with all supplements, we should be careful to stay vigilant for potential side effects. In the case of CoQ10, pets with heart disease may find the energy-increasing properties of normal CoQ10 to be somewhat risky, as cells within the circulatory system will become energized at a much faster rate than normal. Under the right conditions, this could potentially lead to the heart muscle becoming unable to properly regulate its beat and have dire consequences for your dog. Fortunately, there is an alternative form of the supplement available which is safe for use by animals with circulatory issues. This is marketed under the name ‘Ubiquinol’. The core difference between this substance and basic CoQ10 is that Ubiquinol causes cells to shed electrons faster, instead of accepting them. This still speeds up the production of energy, but does not impart a charge to the cell that may prove disruptive to the nerves in the heart.
Ubiquinol vs Ubiquinone
Because ubiquinol costs more to manufacture it is more expensive for consumers to purchase and for scientists to use in research. Ironically, CoQ10 shifts between its ubiquinone
and ubiquinol form in a continuous cycle inside the body.
This is all part of CoQ10’s role in biology. So when you take ubiquinol it shifts to ubiquinone and vice versa. It possible makes no difference in what form you take the substance.
• Ubiquinone (oxidized form) is essential for CoQ10’s role in cellular energy metabolism (ATP synthesis)
• Ubiquinol (reduced form) is essential for the antioxidant
Depending on whether CoQ10 is in the blood and lymph or inside the mitochondria of the cells, it shifts to the form that is needed in the particular situation. In blood and lymph,
CoQ10 primarily serves as an antioxidant. In the mitochondria, it supports the energy metabolism.
Ubiquinol vs Ubiquinone bioavailability
Increased bioavailability of ubiquinol compared to that of ubiquinone is due to more efficient micellarization during digestion and greater GSH-dependent uptake and basolateral secretion by Caco-2 cells.
Ubiquinol vs Ubiquinone absorption
Ever since the discovery of coenzyme Q10 in 1957, scientists have been conducting research with this intriguing nutrient that appears to play a crucial role in human health. Another word for coenzyme Q10 is“ubiquinone” because of its omnipotent importance. “Ubi” means everywhere.
In 2006, a new type of CoQ10 called“ubiquinol” surfaced commercially. Clever marketing campaigns attempted to pawn this off as the new and improved CoQ10 source that was absorbed more easily in the body and was superior to ubiquinone. Consumers as well as scientists got confused and started questioning the traditional form of CoQ10 – ubiquinone –although it had been sold commercially and used in studies all along.
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