What were those two words? “Sublingual? Nope.”
What the heck does that mean? Well, let me explain.
Sublingual is a pharmacological route of administration in which molecules are diffused into the bloodstream through the soft tissue under the tongue. Some people think it’s a good way to get NMN into your bloodstream. It’s a good way to get a lot of things into your bloodstream, so they might be right.
Because when it comes to NAD precursors, there’s far more we don’t know than what we do. And, as I’ve said many, many times, the best evidence will come when placebo-controlled human trials (lots of them) have been completed. Until then, anyone who is taking NMN—in any way—is guessing. And, even if they have the best of intentions, anyone who is selling you NMN as a product, and telling you how to take it, is also guessing.
I’ve worked very hard to be very transparent. I’ve told the world, for instance, that I have been taking NMN for some time now. So have many members of my family and plenty of my friends and colleagues. And I’m asked—a lot—about how I take it. So recently I answered: “Sublingual? Nope.”Oh man. A few people were not happy with me.
But here’s the thing: If you’ve been paying attention at all, you know that I don’t give medical advice and I don’t endorse products. In the interest of transparency, though, I have been willing to explain what I do, but always with the caveat that (once again for the people in the back) I don’t give medical advice and I don’t endorse products.This has always been my policy.
So I’m not saying: “Should YOU take sublingual NMN? Nope.”And I’m not saying: “Is sublingual NMN any good? Nope.”I’m saying: “Do I take sublingual? Nope.”
There is literally no other way to read those two words, unless you think that I suddenly changed my mind about giving medical advice and endorsing products. What you’ll get from me is science, along with some disclosures about how I’m trying to apply it to my life. And that’s it. I do believe that we’re on the cusp of fundamentally shifting the way humans think about aging. NMN might play a big role in that shift. Or it might be a blip on the radar as we move onward and upward. Time will tell.
But if you think that listening to me has any value whatsoever as our world moves in this bold new direction, know this: I’m going to do my very best to help you understand the science, and I’m going to be as transparent as possible about my own life, but I’m NOT going to tell you how to live yours. I've got this subject on my mind today because, whenever a new study about boosting NAD hits the presses, my inbox explodes.
Take, for instance, what happened in the wake of some recent research out of Richard Goodman’s lab at Oregon Health & Science University. The paper, published in Proceedings of the National Academy of Sciences, provides evidence that a known NAD-booster, NMN, enhances the SARM1-mediated neurotoxicity of vincristine, a cancer chemotherapeutic agent.
In another paper, from researchers at the University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, one dose of NMN increased mitochondrial NAD+ in mouse brains for 24 hours, and raised chemical energy levels, too.
Sometimes, when papers like this are published, the reaction is:HEY EVERYBODY! NMN HAS THIS SCARY EFFECT AND OH MY GOD IT’S GOING TO KILL US ALL AND WE SHOULD TAKE MORE NR INSTEAD!!!
Other times, the reaction is: HEY EVERYBODY! NMN HAS THIS INCREDIBLE EFFECT AND LET’S ALL GO OUT AND BUY LOTS OF NMN INSTEAD OF NR!!! My reaction? “Hmmm. Interesting.”
Let me be clear here: I do get excited about results like those published in these papers. More knowledge is always better than none. What I don’t do is make my decisions about the comparative efficacy of Nicotinamide mononucleotide or Nicotinamide riboside (or anything else) based on any one paper.
It’s no secret that I take NMN; I’ve been very up front about that. I would consider it to be an act of dishonesty to not disclose that fact. It also should not be a secret at this point that I have absolutely no opinion whatsoever on whether anyone else should take these supplements. I’m a professor and researcher, not a salesman or representative from an analytics company, so I’m unable to advise where to get it, how to take it, or whether or not you should give it to your pet chinchilla.
By the way, if you see my name on a product’s website, it is being used without my permission. I don’t sell supplements. With 25 years of experience in this field, and having read thousands of papers on this subject, I can give you my interpretation of the scientific literature, and my thoughts on some of the politics surrounding these molecules.
Whenever you or I are seeking to interpret scientific studies — in a way, for instance, that allows us to make decisions about the difference between NMN and NR — we all need to remember that:
1. Cell culture results are trumped by mouse results.
2. Mouse results are trumped by human results.
3. Anecdotes and small human trial results, while certainly interesting and sometimes even exciting, are trumped by double-blind placebo controlled studies.
4. Approved drugs, of course, trump all of that — and even then we absolutely must push onward with more research, more research, and more research. Our jobs are never done. Our curiosity should never be satisfied.
Best Way to Take NMN
NMN supplements have not been approved by the FDA for medical use. In general, regulatory bodies aren’t assuring the quality, safety, and efficacy of supplements. Speak with your doctor before supplementing.
NMN is currently marketed as a pill and in powder form.
Companies selling NMN as a supplement claim that taking it orally is effective in boosting NAD. This claim is based on the discovery of Slc12a8, the protein which helps absorb NMN in the gut .
The company ALIVE BY NATURE markets a sublingual (under the tongue) formulation of NMN that they claim is more likely to be absorbed into the bloodstream.
It’s worth mentioning that a one-time purchase of 10 g of NMN from RevGenetics comes with a hefty price-tag of $195.
How much nmn to take per day?
Nicotinamide mononucleotide (NMN) is a precursor to NAD with purported anti-aging effects. It may combat oxidative stress and cell damage by activating the sirtuins and extending telomeres.
In turn, NMN may improve aging-related brain, heart, and metabolic diseases. However, none of its potential benefits have been confirmed in clinical trials. NMN is similar to nicotinamide riboside (NR); it supposedly has better absorption and effectiveness, but the research is limited.
NMN can be taken orally as a pill/powder or under the tongue. Clinical studies currently underway are using around 250 mg per day. Due to the lack of safety data, make sure to consult with your doctor before using NMN.
NMN side effects
When taken by mouth: Nicotinamide riboside is POSSIBLY SAFE when used short-term. Side effects of nicotinamide riboside are usually mild. Side effects may include stomach problems such as nausea and bloating or skin problems such as itching and sweating too much.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if nicotinamide riboside is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
If you need to buy NMN bulk powder, please contact us at email: firstname.lastname@example.org