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Citrus Bioflavonoids

Citrus Bioflavonoids

Description:Citrus Bioflavonoids Powder
Latin Name: Citrus aurantium L.
Specification Ratio: 4:1~20:1 flavones 20% Synephrine HCL 50%, 99%; 80mesh Powder
Part Used: Peel, Fruit
Specification: 10~60% Flavone;
Appearance: Brown Powder,white;
Test Method: TLC;

What is Citrus Bioflavonoids?

Citrus bioflavonoids and related substances are widely used in Europe to treat diseases of the blood vessels and lymph system, including hemorrhoids, chronic venous insufficiency, leg ulcers, easy bruising, nosebleeds, and lymphedema following breast cancer surgery. These compounds are thought to work by strengthening the walls of blood vessels. Bioflavonoids are also often said to act as antioxidants; however, while they do have antioxidant activity in the test tube, growing evidence suggests that they do not act as antioxidants in people.

citrus bioflavonoids benefits





Test method

Assay(Total flavonoids)

45.0% Min




10.0% Min




20.0% Min




Brown-yellow fine powder








Total Plate Count

1,000cfu/g Max



citrus bioflavonoids dosage

Citrus Bioflavonoids Benefits:

1.Citrus Bioflavonoids Protect Mitochondria

Citrus bioflavonoids in general are established regulators of mitochondrial health through improving antioxidant status, increasing energy production, promoting biogenesis, regulating mitophagy, and altering morphology. Many of these effects are seen with citrus bioflavonoids specifically.

For example, in mice, hesperetin directly increases mitochondrial biogenesis, antioxidant defenses, and ATP production, while also reducing oxidative stress and attenuating muscular impairments that come with old age.

2.Citrus Bioflavonoids Protect Blood Vessels

Similarly, in endothelial cells that make up the lining of our blood vessels, hesperidin increased the activation of several signaling molecules involved in mitochondrial biogenesis, including Akt and AMPK, increased concentrations of nitric oxide, and reduced the expression of adhesion molecules involved in atherosclerosis [8].

What’s cool about this study is that the researchers then went on to have obese adults with metabolic syndrome supplement with 500 mg of hesperidin per day for 3 weeks to see how these effects played out in real life. They found that flow-mediated dilation, a marker for endothelial function, increased by 25%, and that C-reactive protein, a marker of systemic inflammation, was reduced by 33%.

If the goal is to protect your nutrient highway and ensure adequate oxygen and nutrition reach your brain, muscles, and mitochondria, then citrus bioflavonoids are going to do you wonders through protecting your blood vessels.

3.Citrus Bioflavonoids Boost Performance

The mitochondrial-bolstering effects are evident in athletes as well. In recreationally active men, daily supplementation with 500 mg per day of hesperidin led to a 5% greater average power output than the placebo group after one month [9]. This was accompanied by a lower oxygen requirement to produce a given power output, meaning that the participants using hesperidin were more efficient with using their energy, likely through enhanced mitochondrial function.

Similarly, when trained cyclists supplement with 500 mg of hesperidin before exercising, they experience significant increases in their performance and power output during a sprint test. The effects weren’t huge, amounting to a 2–4% benefit over placebo, but that could be the difference between first and second place in a race or even just being able to complete a daily chore.

4.Citrus Bioflavonoids Reduce Blood Lipids

Lastly, there have been a variety of studies showing that citrus bioflavonoid supplementation reduces blood lipids in those with elevated levels. For example, in adults with dyslipidemia, daily supplementation with 270 mg of citrus flavonoids and 30 mg of tocotrienols reduced LDL-C by 19–27% and triglycerides by 24–34% .

Other studies have documented that 500 mg/d of hesperidin for 6–24 weeks reduces triglycerides [12,13], and that 400 mg/d of naringin for 8 weeks reduces LDL-C [14]. In both cases, the effects occurred only in those with elevated levels to begin with, suggesting that citrus bioflavonoids work to normalize health status.

Citrus bioflavonoids dosage

Usual Adult Dose for Osteoarthritis:

Bioflavonoids 250 mg oral capsule:

250 mg orally every 12 hours or 3 times a day.

Citrus Bioflavonoids Application:

1. As Food and beverage ingredients.
2. As Healthy Products ingredients.
3. As Nutrition Supplements ingredients.
4. As Pharmaceutical Industry & General Drugs ingredients.
5. As a health food and cosmetic ingredients

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