Piperine, along with its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper. It has been used in some forms of traditional medicine.
Piperine extract and is the only product able to increase the bioavailability of nutritional compounds that is supported by proper testing and certification. Pure piperine extract is also known as a thermonutrient and may assist by enhancing internal processes within the human or animal. This natural ingredient may be added to foods and beverages or smoothies and green drinks. It is a light to medium gray powder and has no fillers or binders, additives or preservatives. Various sizes available for personal use and quantity discounts available on bulk-packed foods and food powders for commercial uses.
Piper Nigrum L.
Pepper is the most basic ingredient in Indian medicine and is used to treat many diseases. Pharmacological studies have proved many of their traditional medicinal effects such as: analgesic and antipyretic effects, antioxidant effects, antibacterial effects, etc. Piperine is an effective ingredient of pepper. Piperine has a wide range of pharmacological effects, and has been found to have anti-oxidation, immune regulation, and anti-tumor effects.
There are many reports on the anti-tumor effects of piperine. Studies have found that piperine extract can inhibit lung metastasis induced by B16F-10 melanoma, significantly reduce tumor formation, and prolong the survival of tumor-bearing mice. This shows that piperine has anti-tumor metastasis effects. Studies have found that oral piperine can significantly reduce the lipid peroxidation level, nucleotide content and polyamine synthesis in mice with benzopyrene-induced lung cancer. Its inhibitory mechanism is to protect protein from damage and inhibit cell proliferation. In the melanoma cell model, piperine can effectively inhibit the gene expression of ATF-2, NF-kappab and inflammatory cytokines.
Based on the DPPH-free radical generation system, the ability of piperine to scavenge this kind of free radicals in anhydrous ethanol medium was studied. Its ability to scavenge free radicals can indicate the strength of its antioxidant capacity. Studies have shown that piperine has a certain antioxidant activity, its antioxidant capacity is equivalent to 60.05% of vitamin C, and it exists stably in acidic media.
3. Effects on the central nervous system
At present, studies have proved that piperine has various effects such as sedation, hypnosis, anticonvulsions, skeletal muscle relaxation and antidepression. The study of the effect of pure piperine extract on animal sleep has found that piperine can significantly reduce the autonomous activities of mice, and significantly Extending the sleep time of mice induced by sodium pentobarbital can also significantly increase the deep sleep of rabbits. The mechanism may be related to the increase of serotonin content in the brain.
4. Immune regulation
The immunotoxicological study of piperine extract showed that the mice had no obvious toxic effects when gavage piperine extract for five consecutive days, and the liver weight increased normally. When studying the effect of piperine on thymocytes, it was found that piperine can inhibit the production of reactive oxygen species (ROS) and increase the content of glutathione (GSH), and inhibit cell apoptosis and changes in the phenotype of thymus-dependent lymphocytes.
5. Reduce inflammation
Pure piperine extract can reduce inflammation and pain. Oral piperine at a dose of 50 mg/kg can significantly reduce the occurrence of inflammation. Piperine has an anti-inflammatory effect. Piperine and its congeners can be absorbed through the skin, so it can act on subcutaneous tissues, nerves and blood vessels. In addition, pharmacological studies have shown that piperine can prevent atherosclerosis, lower blood lipids, have anticonvulsant and antiulcer activities, protect the liver, and will not damage the function of the testicles. And whether in the body or outside of the body, piperine can also slow down the peristalsis of the intestines. The effect of piperine on the nervous system and sexual organs reflects its anti-convulsant and vasodilator properties.
1. As pharmaceutical raw materials for arthritis, rheumatism, anti-inflammation, detumescence and so on, it is mainly used in pharmaceutical field;
2. As products effective ingredients for improving blood circulation and soothing the nerves, it is mainly used in health product industry;
3. As active ingredients of skin care products, it is mainly used in cosmetic industry.
In North America, an average diet contains about 360 mg of black pepper per day or about 18–32 mg of piperine. Black pepper consists of 5%–9% piperine.Doses of 5–10 mg of piperine are given concomitantly with nutritional supplements (such as turmeric and resveratrol) to enhance absorption.
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